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Important Safety Information

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Side Effects Associated with CLOZARIL

As with any medication, certain side effects are associated with CLOZARIL. Some of the side effects that have been reported when therapy is started disappear with time or after the healthcare professional adjusts the dosage. In some cases the side effects require treatment. The healthcare professional, or another member of the treatment team, can give advice on how to recognize potential side effects and what to do about them.

In addition to agranulocytosis (the most serious side effect associated with CLOZARIL), the following side effects have been reported:

  • Seizures or convulsions: The higher the dosage, the greater the risk of seizures. Also, people who have had seizures in the past are more likely to have them with CLOZARIL. If a person suffers a seizure, he or she should tell their healthcare professional at once.
  • Fast or irregular heartbeat: If this happens, the dosage may be reduced, or this side effect may be treated with another medication.
  • Myocarditis (an inflammation of a muscle in the heart): The risk is greatest during the first month of CLOZARIL therapy.
  • Orthostatic hypotension (a fall in blood pressure when suddenly standing up): The risk is highest when treatment with CLOZARIL is started.
  • Other less serious reported side effects are drowsiness, heavy drooling, headache, constipation, fever, fatigue, nausea, and weight gain. Because healthcare professionals are familiar with these and other possible side effects, they can offer advice on relieving them.


Please see the Full Prescribing Information.

 
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